| 田莹，檀军，赵帅，郭建军,2020,九香虫水煎液主要成分分析及对乳腺癌细胞增殖的抑制作用[J].环境昆虫学报,(2):299-305 |
| 九香虫水煎液主要成分分析及对乳腺癌细胞增殖的抑制作用 |
| Main components and anti proliferative activities of Aspongopus chinensis decoction on breast cancer cells |
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| DOI： |
| 中文关键词: 九香虫 水煎液 成分 乳腺癌 |
| 英文关键词:Aspongopus chinensis Dallas decoction components breast cancer |
| 基金项目:国家自然科学基金项目（81803968，81360612） |
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| 中文摘要: |
| 为检测九香虫水煎液对乳腺癌细胞体外增殖的影响及分析其主要成分，通过制备九香虫水煎液，利用MTT法、形态学观察及细胞划痕实验检测九香虫水煎液对人乳腺癌细胞MDA-MB-453及小鼠乳腺癌细胞4T1增殖和迁移的影响，采用GC-MS技术分析九香虫水煎液的主要化学成分。结果表明，九香虫水煎液对人乳腺癌MDA-MB-453及小鼠乳腺癌4T1细胞的体外增殖具有显著的抑制作用，且呈剂量相关性，IC50分别为0.034、0.101 g/mL，其对4T1细胞的迁移具有抑制作用。九香虫水煎液对乳腺癌细胞的增殖及迁移抑制作用可能与其中含有具抗肿瘤功效的反丁烯二酸、3, 4二羟基苯甲酸、腺苷、尿苷、棕榈酸等物质相关。 |
| 英文摘要: |
| To detect the effects of Aspongopus chinensis Dallas decoction on the proliferation of breast cancer cells and analyze the decoction's main components MTT assay and morphological observation were used to detect the effects of decoction on the proliferation of MDA-MB-453 of human breast cancer cells and 4T1 of mouse breast cancer cells. The main chemical components of the decoction were analyzed by GC-MS. The results showed that the decoction caused a dose dependent inhibition on the proliferation of MDA-MB-453 and 4T1 cells, and the IC50 values were 0.034 and 0.101 g/mL, respectively. Moreover, the decoction could inhibit the migration of 4T1 cells. The inhibitory effect of the decoction on the proliferation and migration of breast cancer cells may be related to the presence of fumaric acid, 3, 4- dihydroxybenzoic acid, adenosine, uridine and palmitic acid, etc. |
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