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| 昆虫性别决定研究进展 |
| Progress on insect sex determination |
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| DOI： |
| 中文关键词: 昆虫性别决定 初始信号 doublesex 可变剪切 |
| 英文关键词:Sex determination primary signal doublesex alternative splicing |
| 基金项目:国家重点研发计划（2021YFD1401100）；湖南省青年科技人才项目（2022RC1025） |
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| 中文摘要: |
| 昆虫作为通过可变剪切调控性别决定的生物，拥有着保守性与多样性并存的性别决定机制。快速进化的上游性别决定初始信号使得几乎共享相同基因组的两性个体在形态、生理、行为等方面上有着巨大差异，而下游的双性基因doublesex在结构和功能上高度保守。本文综述了昆虫性别决定调控机制中初始信号的作用机理，概括了下游信号通路的响应机制，介绍了性别决定下游保守基因doublesex，以期为深入理解昆虫性别决定机制和农业害虫防治提供新思路。 |
| 英文摘要: |
| In insects, the determination of sex involves a sophisticated mechanism governed by alternative splicing, which allows for a coexistence of conservatism and diversity. The rapid evolution of upstream sex determination primary signals leads to significant morphological, physiological, and behavioral differences between individuals of the two sexes, despite sharing nearly identical genomes. Conversely, the downstream gene doublesex exhibits a high degree of conservation in both structure and function. This article reviews the mechanistic role of primary signals in regulating sex determination in insects, summarizes the response mechanisms of downstream signaling pathways, and introduces the conserved gene doublesex as a key player in sex determination. The aim is to provide new insights for a deeper understanding of the mechanisms underlying insect sex determination and contribute to novel perspectives in the context of agricultural pest control. |
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