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| 昆虫锌金属蛋白酶研究进展 |
| Advancement on zinc metalloproteases in insects |
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| DOI： |
| 中文关键词: 锌金属蛋白酶 家族分类 消化 发育 变态 免疫 |
| 英文关键词:Zinc metalloproteases family classification digestion development metamorphosis immune |
| 基金项目:国家自然科学基金 (32072492，31672086) ; 国家重点研发项目 (2017YFC1200604) |
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| 中文摘要: |
| 锌金属蛋白酶是指含有锌离子的蛋白酶，在哺乳动物中参与多项生物学过程的调控。在昆虫中也发现了许多锌金属蛋白酶，能够参与昆虫体内多项生命活动进程如食物的消化与吸收、组织重塑、变态发育、神经系统的调控及免疫防御反应等。本文综述了目前在昆虫中发现的锌金属蛋白酶的结构和底物特异性，聚焦 6 种锌金属蛋白酶 ( 羧肽酶、基质金属蛋白酶、脑啡肽酶、胰岛素降解酶、血管紧缩素转换酶及氨肽酶) 在昆虫中的功能，旨 在为昆虫锌金属蛋白酶的深入研究提供参考。 |
| 英文摘要: |
| Zinc metalloproteases are those proteases containing zinc ion，which participate in regulation of many physiological processes in mammals. Many zinc metalloproteases have also been found in insects， and they are involved in many life activities，such as digestion and absorption of food，tissue remodeling， metamorphosis，regulation of central nervous system and immune defense response. In the present paper，the structure and substrate specificity of zinc metalloproteases found in insects were reviewed with focusing on the functions of six zinc proteases ( carboxypeptidase，matrix metalloprotease，neprilysin，insulin degrading enzyme，angiotensin converting enzyme and aminopeptidase) ，aiming to provide reference for further investigation of zinc metalloproteases in insects. |
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