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| 昆虫毒蕈碱型乙酰胆碱受体的研究进展 |
| Advances in insect muscarinic acetylcholine receptors |
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| DOI： |
| 中文关键词: 昆虫 毒蕈碱乙酰胆碱受体 药理学 生理功能 |
| 英文关键词:Insect muscarinic acetylcholine receptor pharmacology physiological function |
| 基金项目:国家自然科学基金项目（31801741）；农业农村部农作物病虫鼠害疫情综合防控项目（15206036） |
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| 中文摘要: |
| 毒蕈碱型乙酰胆碱受体（Muscarinic Acetylcholine Receptors，mAChRs）是昆虫神经系统中一类重要的G蛋白偶联受体。昆虫mAChRs可以分为A、B、C型三大类，它们通过偶联不同的G蛋白激活不同的第二信使，完成信号转导过程，从而发挥其功能。mAChRs参与调控昆虫多种生理反应和行为过程，如生长发育、运动、鸣声、嗅觉以及学习记忆等，是潜在的杀虫剂靶标，对昆虫mAChRs的全面研究有助于开发新型杀虫剂。本文较为全面地综述了近年来国内外昆虫mAChRs的组织分布、信号转导、药理学特性以及生理功能等方面的研究新进展，为今后研究该类受体提供参考。 |
| 英文摘要: |
| Muscarinic acetylcholine receptors (mAChRs), are mainly G-protein-coupled receptors in insect nervous system. There are three subtypes of insect mAChRs, namely mAChR-A, mAChR-B and mAChR-C. These receptors initiate different second-messenger pathways via coupling different G-proteins. mAChRs are involved in the regulation of a variety of physiological responses and behavioral processes in insects, such as growth and development, locomotion, stridulation, olfaction, learning and memory. Insect mAChRs are important potential targets of insecticides. In this paper, the recent advances in the tissue distribution, signal transduction, pharmacological properties and physiological roles of insect mAChRs were reviewed, which would provide a reference for further study on those receptors. |
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