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| 昆虫抗菌肽分类及在医学中应用 |
| Classification of insect antimicrobial peptides and its applications in medicine |
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| DOI： |
| 中文关键词: 抗菌肽 昆虫 种类 医学应用 |
| 英文关键词:Antimicrobial peptides insect classification medical applications |
| 基金项目:国家自然科学基金项目（31260528）；贵州省教育厅创新群体重大研究项目（黔教合KY字\[2016\]037）；广东省医学科研基金（A2012621）；贵州省科学技术基金（黔科合J字\[2009\]2295号） |
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| 中文摘要: |
| 昆虫是地球上种类最为繁多的生物，其抗菌肽的种类和应用范围也远多于其他生物产生的抗菌肽。随着越来越多昆虫抗菌肽的发现及对其深入的研究，昆虫抗菌肽的结构和作用机制也被逐一阐明，并广泛应用于畜牧、食品工业及医药等领域。然而，由于某些限制因素，昆虫抗菌肽还未应用于临床。为了加快昆虫抗菌肽在临床中的应用，本文将从昆虫抗菌肽的结构分类、潜在的医学应用以及昆虫抗菌肽的生产研究现状等方面作一综述，以期为昆虫抗菌肽在抗细菌、抗病毒、抗肿瘤及抗寄生虫药物等方面的医用研发提供文献支持。 |
| 英文摘要: |
| Insects are the most diverse biological species on earth, and insect antimicrobial peptides also exhibited more biological activities than those produced by other organisms. Furthermore, the structure, and its effects and mechanisms were gradually elucidated with the increasing research on antibacterial peptides. Recently, they were widely used in the field of animal husbandry, food industry and medicine. However, insect antibacterial peptides were not applied to the patients till now. In order to progress the application of insect antibacterial peptides in clinical application, this manuscript reviewed the structure, the classification, its potential medical applications and the production of insect antibacterial peptides. We hope it could provide the theoretical support for the research and development of insect antibacterial peptides used for antibacterial, antiviral, antitumor and antiparasitic drugs. |
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