|
| 昆虫卵黄原蛋白受体( VgＲs) 及其主要功能综述 |
| A review of insect vitellogenin receptors ( VgＲs) and their fundamentalfunctions |
| |
| DOI： |
| 中文关键词: 昆虫 卵黄原蛋白受体 表达模式 生殖调控 功能 |
| 英文关键词:Insect vitellogenin receptor expression profiling reproductive regulation functions |
| 基金项目:国家自然科学基金( 31320103922，31230061，31401744) |
|
| Hits: 897 |
| Download times: 1232 |
| 中文摘要: |
| 卵黄原蛋白受体( VgＲs) 属于低密度脂蛋白受体家族成员，具有该家族典型的保守结构域，包括配体结合域，表皮生长因子前体同源域，跨膜域，O-联糖功能域，以及胞质尾域。昆虫VgＲs 通常具有卵巢特异性，是卵黄原蛋白Vg 的专一性胞吞作用受体，可介导Vg 进入昆虫卵母细胞，而后沉淀积累形成昆虫生殖必须的卵黄蛋白YP。VgＲs 介导的胞吞作用是一个动态循环过程，它是卵黄发生的基础，对昆虫卵母细胞发育起着至关重要的作用。近年来的研究表明，VgＲs 不仅与卵巢激活、卵黄发生与卵子形成密切相关，而且在昆虫信息交流、社会分化、行为构建以及免疫调控等中也起到了至关重要的作用，已成为潜在的害虫控制新靶标。本文首次对昆虫VgＲs 基因的序列信息，分子结构，系统进化，表达模式以及调控功能等方面进行了综述，旨在为了解VgＲs 基因的研究进展及前景提供参考，对进一步改进害虫生态控制的策略和措施也具有指导意义。 |
| 英文摘要: |
| Insect vitellogenin receptors ( VgＲs) belong to the low-density lipoprotein receptor ( LDLＲ) gene superfamily，which share a group of five structural domains: ligand-binding domain ( LBD) ， epidermal growth factor precursor homology domain ( EGFD) ，transmembrane domain ( TMD) ，O-linked sugar domain ( OLSD) ，and cytoplasmic domain ( CPD) ． The expression studies demonstrate that insect VgＲs are usually ovary-bound receptors involved in mediating dynamic endocytosis of the major yolk protein precursors Vg． VgＲ is the basic substance for vitellogenesis，and dominates the oocyte development of insects． In addition，recent advances in this area have shown that insect VgＲs are not only associated with the ovary activation，vitellogenesis，and oogenesis，but also play a critical role in information exchange， labor differentiation，behavior formation，and immune regulation，which has become a potential new target for pest control． This article presents an overview of the research progress in insect VgＲs，including their genomic information，molecular structures，phylogenetic relationships，expression profiles and regulating functions． We believe that this review article addresses available literature，and provides potential prospects with the hope to improve the genetic strategies and tactics currently employed in ecologically-based pest management． |
| View Full Text View/Add Comment Download reader |
| Close |
About Journal