| 吴一弘，陈国庆，王文凯，冯国忠,2021,昆虫中的核输出现象[J].环境昆虫学报,(5):1095-1106 |
| 昆虫中的核输出现象 |
| Nuclear export in insects |
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| DOI： |
| 中文关键词: 昆虫 核孔复合体 核质转运 核输出信号 核输出受体 |
| 英文关键词:Insect nuclear pore complex nucleocytoplasmic transport nuclear export signal exportin |
| 基金项目:国家自然科学基金面上项目（31972983，32072487）；中央级公益性科研院所基本科研业务费(CPSIBRF-CNRRI-202115) |
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| 中文摘要: |
| 核质转运是真核细胞生命活动重要的组成部分，细胞核内蛋白的平衡及转录出的RNA出核成熟过程都依赖于核输出，核输出与真核生物的生命活动密切相关；病原物在侵染昆虫时也会利用宿主的核输出机制干扰宿主的免疫反应或劫持宿主的核输出蛋白以利于病毒的组装及复制。本文主要介绍真核细胞中核输出的基本机制、蚊子和果蝇等模式昆虫中核输出通路；简述核输出机制在昆虫胚胎发育及免疫等生理活动及信号通路中的影响，以及与昆虫相关的病毒蛋白对昆虫等宿主核输出机制的利用和破坏情况。 |
| 英文摘要: |
| Nucleocytoplasmic transport plays an essential role in diverse cellular activities. The protein balance and the transport of RNA from the nucleus depend on the nuclear export, which is closely related to the life processes of eukaryotes. Pathogens also take advantage of host nuclear export mechanism to interfere with host immune response or hijack host nuclear export proteins for viral assembly and replication. This review mainly introduced the mechanism of nuclear export in eukaryotic cells, especially model insects such as mosquitoes and fruit flies, and described the effects of nuclear export mechanism on physiological activities and signal pathways of insect embryonic development and immunity, as well as the utilization and destruction of insect-related viral proteins on the nuclear export mechanism of host insects. |
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