| 黄博，朱梦瑶，丘霈珊，张若男，张文庆，余小强，卢玉珍,2021,核型多角体病毒侵染及其与宿主免疫系统互作的研究进展[J].环境昆虫学报,(2):329-339 |
| 核型多角体病毒侵染及其与宿主免疫系统互作的研究进展 |
| Advance in the research of nucleopolyhedrovirus infection and its interaction with host immune system |
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| DOI： |
| 中文关键词: 核型多角体病毒 杆状病毒 包埋型病毒粒子 芽生型病毒粒子 先天免疫 |
| 英文关键词:Nucleopolyhedrovirus baculovirus occlusion-derived virus budded virus innate immunity |
| 基金项目:国家自然科学基金（31901941）；国家重点研发计划（2019YFD1002100）;中山大学有害生物控制与资源利用国家重点实验室开放课题（2018SKLBC-KF03） |
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| 中文摘要: |
| 核型多角体病毒（Nucleopolyhedrovirus，NPV）应用广泛，已被开发成微生物杀虫剂和用于重组蛋白表达等。NPV具有两种病毒颗粒：包埋型病毒粒子（occlusion-derived virus，ODV）和芽生型病毒粒子（budded virus，BV），两者的构成和组装存在差异。病毒包涵体在肠道中溶解后释放出ODV进行初级感染，子代核衣壳通过质膜出芽产生BV引发全身性的次级感染。病毒感染昆虫后能引发宿主的免疫反应，同时NPV病毒已进化出多种策略抑制或逃避宿主的免疫反应，如免疫信号通路、黑化和凋亡等过程。本文将总结鳞翅目特异性NPV与宿主的互作研究，着重介绍NPV的侵染机制、NPV与宿主免疫系统互作的研究进展。 |
| 英文摘要: |
| Nucleopolyhedrovirus (NPV)has been widely used as a biological control agent and an expression system for recombinant proteins.There are two virion phenotypes, occlusion-derived virus (ODV)and the budded virus (BV), that are distinct in the composition and assembly during the infection cycle. The primary infection occurs when occlusion bodies (OBs)are disassembled to release ODV virions into lumen of the midgut. The progeny nucleocapsids are transported to the plasma membrane to generate BV phenotype. The BV virions may infect other tissues and cause secondary phase of infection. Insects possess efficient innate immune defenses to viral infection, whereas NPV has evolved various strategies to suppress or avoid host immune responses. The interaction processes between NPV and host immune system include immune signaling pathway, melanization and apoptosis. In this paper, we summarize recent studies on the interactions between Lepidopteran-specific nucleopolyhedrovirus and their insect hosts, mainly focus on the mechanisms of infection, and the interaction between NPV and host immune system. |
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