| 高湘滨，叶浩生，王晗玥，刘素宁，罗 威,2025,保幼激素调控昆虫行为的研究进展[J].环境昆虫学报,(4):1030-1037 |
| 保幼激素调控昆虫行为的研究进展 |
| Research progress on juvenile hormone regulation of insect behavior |
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| DOI： |
| 中文关键词: 保幼激素 昆虫行为 生殖调控 社会性行为 |
| 英文关键词:Juvenile hormone insect behavior reproductive regulation insect sociality |
| 基金项目:国家自然科学基金（32470485）；广东省自然科学基金（2023A1515010409） |
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| 中文摘要: |
| 保幼激素（Juvenile hormone，JH）是昆虫体内一类重要的倍半萜类激素，可通过胞内受体（Met/Gce）与膜受体双信号通路，调控昆虫的生长发育、生殖行为、社会行为及环境适应性。在雌性昆虫中，JH诱导卵巢细胞外基质基因表达来促进排卵行为；调控性信息素合成增强交配吸引力，而交配后性肽通过提升JH滴度抑制再交配行为；同时通过与胰岛素信号互作平衡繁殖与能量代谢，影响寿命。雄性行为研究揭示JH调节求偶神经回路（如果蝇FruM神经元）发育而促进性成熟。在社会性昆虫中，JH调控品级分化和生殖分工，维持群体的稳定。然而，JH膜信号的分子机制、组织特异性及与胞内受体的时空调控网络仍属空白；其在雌性性信息素快速合成和雄性求偶神经回路中的行为开关机制亦未厘清。未来可整合单细胞多组学、活体钙成像与AI-行为耦合模型，以揭示JH双通路如何协同编码行为决策，为精准行为干预提供精准目标。本文综述了近年来关于JH信号通路在昆虫行为调控中的作用及其分子机制的研究进展。深入理解JH如何协调昆虫行为，不仅有助于解析昆虫生态适应规律，也为害虫防治和益虫利用提供了理论支持。 |
| 英文摘要: |
| Juvenile hormone (JH), a vital sesquiterpenoid hormone in insects, regulates growth, reproduction, social behavior, and environmental adaptation through dual signaling pathways involving intracellular receptor (Met/Gce) and membrane receptor. In female insects, JH promotes ovulation by inducing extracellular matrix gene expression, enhances mating attractiveness through sex pheromone regulation, and inhibits re-mating post-copulation by elevating JH levels via sex peptides. It also interacts with insulin signaling to balance reproduction, energy metabolism, and lifespan. In male insects, JH facilitates sexual maturation by regulating courtship neural circuits, such as FruM neurons in fruit flies. In social insects, JH governs caste differentiation and reproductive division of labor, ensuring colony stability. Nevertheless, the molecular mechanism of JH membrane signaling, tissue specificity and spatiotemporal coordination with intracellular receptors remain unknown, and their roles as rapid switches in female pheromone bursts and male courtship circuits have not been resolved. Future integration of single-cell multi-omics, in-vivo calcium imaging and AI-behavior coupling model is required to decipher how intracellular and membrane JH pathways jointly encode behavioural decisions, thereby providing precision targets for precise behavioral interventions. This review focuses on recent advances in understanding the role and molecular mechanisms of the JH signaling pathways in insect behavior regulation. Elucidating how JH coordinates insect behavior offers insights into insect ecological adaptation and supports pest control and beneficial insect utilization strategies. |
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